- Ennis & Ennis

01/04/2012 - A recent study conducted by the National Institute of Neurological Disorders (NINDS) to determine if Plavix-aspirin therapy could prevent recurring strokes in people who had recently suffered subcortical strokes was halted after patients on Plavix-aspirin therapy suffered a higher-than-expected number of bleeding events compared to subjects taking aspirin alone. The Plavix-Aspirin arm involved 3,000 patients.

The Wall Street Journal stated that patients in the study treated with the Plavix-aspirin combo also suffered a higher death rate compared to those on aspirin only.

According to the Journal, 6.5% of patients on Plavix-aspirin therapy combination experienced a bleeding event, versus 3.3% of those on aspirin alone. The death rate among people in the combo therapy group was 5.8% versus 4.1% in the aspirin-only group.

In addition to the higher bleeding and death rates, the Plavix-aspirin arm of the study was unable to demonstrate that combo therapy provided any additional benefit in preventing strokes.

According to the Journal, the arm of the SPS3 study testing whether blood-pressure medications can prevent strokes and cognitive decline will continue.

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